diff --git a/CMakeLists.txt b/CMakeLists.txt
index 65876d5a2..4ef2ca22e 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -484,6 +484,9 @@ int main(void) { return 0; }
     elseif(CYGWIN)
       # libuv does not support Cygwin
       set(CMAKE_USE_LIBUV 0)
+    elseif(CMAKE_SYSTEM_NAME STREQUAL "HP-UX")
+      # Disable until it can be ported.
+      set(CMAKE_USE_LIBUV 0)
     elseif(CMAKE_SYSTEM_PROCESSOR MATCHES "sparc")
       # Disable until it can be ported.
       set(CMAKE_USE_LIBUV 0)