diff --git a/Modules/Compiler/GNU.cmake b/Modules/Compiler/GNU.cmake
index 0827e437a..faad41672 100644
--- a/Modules/Compiler/GNU.cmake
+++ b/Modules/Compiler/GNU.cmake
@@ -45,7 +45,7 @@ macro(__compiler_gnu lang)
   set(CMAKE_${lang}_FLAGS_DEBUG_INIT "-g")
   set(CMAKE_${lang}_FLAGS_MINSIZEREL_INIT "-Os -DNDEBUG")
   set(CMAKE_${lang}_FLAGS_RELEASE_INIT "-O3 -DNDEBUG")
-  set(CMAKE_${lang}_FLAGS_RELWITHDEBINFO_INIT "-O2 -g")
+  set(CMAKE_${lang}_FLAGS_RELWITHDEBINFO_INIT "-O2 -g -DNDEBUG")
   set(CMAKE_${lang}_CREATE_PREPROCESSED_SOURCE "<CMAKE_${lang}_COMPILER> <DEFINES> <FLAGS> -E <SOURCE> > <PREPROCESSED_SOURCE>")
   set(CMAKE_${lang}_CREATE_ASSEMBLY_SOURCE "<CMAKE_${lang}_COMPILER> <DEFINES> <FLAGS> -S <SOURCE> -o <ASSEMBLY_SOURCE>")
   if(NOT APPLE)
diff --git a/Modules/Compiler/Intel-ASM.cmake b/Modules/Compiler/Intel-ASM.cmake
index 1f064c9d3..74ceb0a6a 100644
--- a/Modules/Compiler/Intel-ASM.cmake
+++ b/Modules/Compiler/Intel-ASM.cmake
@@ -4,7 +4,7 @@ set(CMAKE_ASM_FLAGS_INIT "")
 set(CMAKE_ASM_FLAGS_DEBUG_INIT "-g")
 set(CMAKE_ASM_FLAGS_MINSIZEREL_INIT "-Os -DNDEBUG")
 set(CMAKE_ASM_FLAGS_RELEASE_INIT "-O3 -DNDEBUG")
-set(CMAKE_ASM_FLAGS_RELWITHDEBINFO_INIT "-O2 -g")
+set(CMAKE_ASM_FLAGS_RELWITHDEBINFO_INIT "-O2 -g -DNDEBUG")
 
 if(UNIX)
   set(CMAKE_ASM_SOURCE_FILE_EXTENSIONS s;S)
diff --git a/Modules/Compiler/Intel-C.cmake b/Modules/Compiler/Intel-C.cmake
index bca86a0f4..e23317c14 100644
--- a/Modules/Compiler/Intel-C.cmake
+++ b/Modules/Compiler/Intel-C.cmake
@@ -4,7 +4,7 @@ set(CMAKE_C_FLAGS_INIT "")
 set(CMAKE_C_FLAGS_DEBUG_INIT "-g")
 set(CMAKE_C_FLAGS_MINSIZEREL_INIT "-Os -DNDEBUG")
 set(CMAKE_C_FLAGS_RELEASE_INIT "-O3 -DNDEBUG")
-set(CMAKE_C_FLAGS_RELWITHDEBINFO_INIT "-O2 -g")
+set(CMAKE_C_FLAGS_RELWITHDEBINFO_INIT "-O2 -g -DNDEBUG")
 
 set(CMAKE_C_CREATE_PREPROCESSED_SOURCE "<CMAKE_C_COMPILER> <DEFINES> <FLAGS> -E <SOURCE> > <PREPROCESSED_SOURCE>")
 set(CMAKE_C_CREATE_ASSEMBLY_SOURCE "<CMAKE_C_COMPILER> <DEFINES> <FLAGS> -S <SOURCE> -o <ASSEMBLY_SOURCE>")
diff --git a/Modules/Compiler/Intel-CXX.cmake b/Modules/Compiler/Intel-CXX.cmake
index 354bb1759..ae6021a68 100644
--- a/Modules/Compiler/Intel-CXX.cmake
+++ b/Modules/Compiler/Intel-CXX.cmake
@@ -4,7 +4,7 @@ set(CMAKE_CXX_FLAGS_INIT "")
 set(CMAKE_CXX_FLAGS_DEBUG_INIT "-g")
 set(CMAKE_CXX_FLAGS_MINSIZEREL_INIT "-Os -DNDEBUG")
 set(CMAKE_CXX_FLAGS_RELEASE_INIT "-O3 -DNDEBUG")
-set(CMAKE_CXX_FLAGS_RELWITHDEBINFO_INIT "-O2 -g")
+set(CMAKE_CXX_FLAGS_RELWITHDEBINFO_INIT "-O2 -g -DNDEBUG")
 
 set(CMAKE_CXX_CREATE_PREPROCESSED_SOURCE "<CMAKE_CXX_COMPILER> <DEFINES> <FLAGS> -E <SOURCE> > <PREPROCESSED_SOURCE>")
 set(CMAKE_CXX_CREATE_ASSEMBLY_SOURCE "<CMAKE_CXX_COMPILER> <DEFINES> <FLAGS> -S <SOURCE> -o <ASSEMBLY_SOURCE>")
diff --git a/Modules/Compiler/SunPro-ASM.cmake b/Modules/Compiler/SunPro-ASM.cmake
index 97776da93..2fa8b9950 100644
--- a/Modules/Compiler/SunPro-ASM.cmake
+++ b/Modules/Compiler/SunPro-ASM.cmake
@@ -12,7 +12,7 @@ set(CMAKE_ASM_FLAGS_INIT "")
 set(CMAKE_ASM_FLAGS_DEBUG_INIT "-g")
 set(CMAKE_ASM_FLAGS_MINSIZEREL_INIT "-xO2 -xspace -DNDEBUG")
 set(CMAKE_ASM_FLAGS_RELEASE_INIT "-xO3 -DNDEBUG")
-set(CMAKE_ASM_FLAGS_RELWITHDEBINFO_INIT "-g -xO2")
+set(CMAKE_ASM_FLAGS_RELWITHDEBINFO_INIT "-g -xO2 -DNDEBUG")
 
 # Initialize ASM link type selection flags.  These flags are used when
 # building a shared library, shared module, or executable that links
diff --git a/Modules/Compiler/SunPro-C.cmake b/Modules/Compiler/SunPro-C.cmake
index 9e36051e4..c5b5203fd 100644
--- a/Modules/Compiler/SunPro-C.cmake
+++ b/Modules/Compiler/SunPro-C.cmake
@@ -12,7 +12,7 @@ set(CMAKE_C_FLAGS_INIT "")
 set(CMAKE_C_FLAGS_DEBUG_INIT "-g")
 set(CMAKE_C_FLAGS_MINSIZEREL_INIT "-xO2 -xspace -DNDEBUG")
 set(CMAKE_C_FLAGS_RELEASE_INIT "-xO3 -DNDEBUG")
-set(CMAKE_C_FLAGS_RELWITHDEBINFO_INIT "-g -xO2")
+set(CMAKE_C_FLAGS_RELWITHDEBINFO_INIT "-g -xO2 -DNDEBUG")
 
 # Initialize C link type selection flags.  These flags are used when
 # building a shared library, shared module, or executable that links
diff --git a/Modules/Compiler/SunPro-CXX.cmake b/Modules/Compiler/SunPro-CXX.cmake
index af31c7bc9..59687129a 100644
--- a/Modules/Compiler/SunPro-CXX.cmake
+++ b/Modules/Compiler/SunPro-CXX.cmake
@@ -12,7 +12,7 @@ set(CMAKE_CXX_FLAGS_INIT "")
 set(CMAKE_CXX_FLAGS_DEBUG_INIT "-g")
 set(CMAKE_CXX_FLAGS_MINSIZEREL_INIT "-xO2 -xspace -DNDEBUG")
 set(CMAKE_CXX_FLAGS_RELEASE_INIT "-xO3 -DNDEBUG")
-set(CMAKE_CXX_FLAGS_RELWITHDEBINFO_INIT "-g -xO2")
+set(CMAKE_CXX_FLAGS_RELWITHDEBINFO_INIT "-g -xO2 -DNDEBUG")
 
 # Initialize C link type selection flags.  These flags are used when
 # building a shared library, shared module, or executable that links
diff --git a/Modules/Compiler/SunPro-Fortran.cmake b/Modules/Compiler/SunPro-Fortran.cmake
index 223a6c66a..18e75b9e3 100644
--- a/Modules/Compiler/SunPro-Fortran.cmake
+++ b/Modules/Compiler/SunPro-Fortran.cmake
@@ -13,6 +13,6 @@ set(CMAKE_Fortran_FLAGS_INIT "")
 set(CMAKE_Fortran_FLAGS_DEBUG_INIT "-g")
 set(CMAKE_Fortran_FLAGS_MINSIZEREL_INIT "-xO2 -xspace -DNDEBUG")
 set(CMAKE_Fortran_FLAGS_RELEASE_INIT "-xO3 -DNDEBUG")
-set(CMAKE_Fortran_FLAGS_RELWITHDEBINFO_INIT "-g -xO2")
+set(CMAKE_Fortran_FLAGS_RELWITHDEBINFO_INIT "-g -xO2 -DNDEBUG")
 set(CMAKE_Fortran_MODDIR_FLAG "-moddir=")
 set(CMAKE_Fortran_MODPATH_FLAG "-M")
diff --git a/Modules/Compiler/TinyCC-C.cmake b/Modules/Compiler/TinyCC-C.cmake
index 178dd0c5e..f7937acdf 100644
--- a/Modules/Compiler/TinyCC-C.cmake
+++ b/Modules/Compiler/TinyCC-C.cmake
@@ -5,4 +5,4 @@ set (CMAKE_C_FLAGS_INIT "")
 set (CMAKE_C_FLAGS_DEBUG_INIT "-g")
 set (CMAKE_C_FLAGS_MINSIZEREL_INIT "-DNDEBUG")
 set (CMAKE_C_FLAGS_RELEASE_INIT "-DNDEBUG")
-set (CMAKE_C_FLAGS_RELWITHDEBINFO_INIT "-g")
+set (CMAKE_C_FLAGS_RELWITHDEBINFO_INIT "-g -DNDEBUG")
diff --git a/Modules/Compiler/XL-ASM.cmake b/Modules/Compiler/XL-ASM.cmake
index 95af2ea53..07507f9be 100644
--- a/Modules/Compiler/XL-ASM.cmake
+++ b/Modules/Compiler/XL-ASM.cmake
@@ -8,6 +8,6 @@ set(CMAKE_ASM_FLAGS_INIT "-qthreaded -qalias=noansi -qhalt=e -qsourcetype=assemb
 set(CMAKE_ASM_FLAGS_DEBUG_INIT "-g")
 set(CMAKE_ASM_FLAGS_RELEASE_INIT "-O -DNDEBUG")
 set(CMAKE_ASM_FLAGS_MINSIZEREL_INIT "-O -DNDEBUG")
-set(CMAKE_ASM_FLAGS_RELWITHDEBINFO_INIT "-g")
+set(CMAKE_ASM_FLAGS_RELWITHDEBINFO_INIT "-g -DNDEBUG")
 
 set(CMAKE_ASM_SOURCE_FILE_EXTENSIONS s )